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Roridin E
Item number: Cay26955-1
Roridin E is a macrocyclic trichothecene mycotoxin that has been found in M. verrucaria. It inhibits the receptor tyrosine kinases FGFR3, IGF-1R, PDGFRbeta, and TrkB (IC50s = 0.4, 0.4, 1.4, and 1 µM, respectively). Roridin E induces cytotoxicity in multiple breast cancer cell lines (IC50s = 0.02-0.05 nM) and...
| Keywords: | (2'E,7'R)-2',3'-didehydro-7'-deoxo-2'-deoxy-7'-[(1R)-1-hydroxyethyl]-verrucarin A |
| Application: | Macrocyclic trichothecene mycotoxin, FGFR3/IGF-1R/PDGFRbeta/TrkB inhibitor |
| CAS | 16891-85-3 |
| MW: | 514.6 D |
From 247.00€
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Roridin E
Item number: AG-CN2-0176-M001
Isolated from fungus Trichoderma sp. Off-white solid. Soluble in ethanol, methanol or DMSO (all 1mg/ml). Mycotoxin. Implicated in human and animal toxicosis. Potent cytotoxic and antiproliferative agent against cancer cell lines. Potent antimalarial agent. Antiviral against arenavirus Junin (JUNV).Antifungal,...
| Keywords: | Satratoxin D, 2',3'-Didehydro-7'-deoxo-2'-deoxy-7'-(1-hydroxy-ethyl)verrucarin A |
| Application: | Cytostatic agent |
| CAS | 16891-85-3 |
| MW: | 514.6 D |
From 110.00€
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Roridin E
Item number: TGM-T70276-1mg
Description: Roridin E inhibits the receptor tyrosine kinases FGFR3, IGF-1R, PDGFRbeta, and TrkB (IC50s = 0.4, 0.4, 1.4, and 1 µM, respectively) and induces cytotoxicity in multiple breast cancer cell lines (IC50s = 0.02-0.05 nM). It also inhibits proliferation in a panel of additional cancer cell lines (IC50s =...
| Application: | Macrocyclic trichothecene mycotoxin, FGFR3/IGF-1R/PDGFRbeta/TrkB inhibitor |
| CAS | 16891-85-3 |
| MW: | 514.61 D |
From 392.00€
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