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Item number: Cay21769-1

Compound 401 is an inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR, IC50s = 0.28 and 5.3 µM, respectively). It is selective for DNA-PK and mTOR over PI3K, ATM, and ATR (IC50s = >100 µM for all). Compound 401 (10 µM) inhibits phosphorylation of the mTOR targets S6K1 and Akt...

Keywords:	2-(4-morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one
Application:	DNA-PK / FRAP inhibitor
CAS	168425-64-7
MW:	281.3 D

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