Cathepsin L inhibitor is a potent inhibitor of cathepsin L (IC50 = 0.85 nM). It is selective for cathepsin L over calpain II and cathepsin B (IC50s = 184, and 85.1 nM, respectively). It is trypanocidal with an ED50 value of 45 nM against T. brucei that is well below the ED50 value of 21,500 nM for human HL-60 cells....

Description: Z-FY-CHO (Z-Phe-Tyr-CHO) is a selective histone L (Cat L) inhibitor that promotes autophagy, reduces the accumulation of P62, and blocks the activation of caspase-3 and PARP. Target: Cysteine Protease, p62. Smiles: [C@H](CC1=CC=CC=C1)(C(N[C@@H](CC2=CC=C(O)C=C2)C=O)=O)NC(OCC3=CC=CC=C3)=O. References:...