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Zosuquidar (hydrochloride)
Item number: Cay21533-5
Zosuquidar is a modulator of P-glycoprotein (P-gp, Ki = 59 nM). It restores the sensitivity of P-gp-expressing cancer cells to vinblastine (Cay-11762), doxorubicin (Cay-15007), etoposide (Cay-12092), and paclitaxel (Cay-10461) when used at 0.1 µM. It less potently inhibits cytochrome P450 (CYP) isoforms CYP3A,...
| Keywords: | LY335979, RS 33295-198,... |
| Application: | P-glycoprotein modulator |
| CAS | 167465-36-3 |
| MW: | 637 D |
From 38.00€
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Zosuquidar trihydrochloride
Item number: TGM-T6018-10mg
Description: Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3. Target: P-gp. Smiles: Cl.Cl.Cl.OC(COc1cccc2ncccc12)CN1CCN(CC1)C1c2ccccc2C2C(c3ccccc13)C2(F)F. References: Dantzig AH, et al. Cancer Res. 1996,...
| Keywords: | Zosuquidar 3HCl, Zosuquidar (LY335979) 3HCl, RS 33295-198 trihydrochloride, RS 33295-198 (D06387) 3HCl, LY-335979... |
| Application: | Targets ATP-binding cassette, subfamily B (MDR/TAP), member 1 [EC:7.6.2.2] (ABCB1, CD243) |
| CAS | 167465-36-3 |
| MW: | 636.99 D |
From 30.00€
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