Description: Omapatrilat is a metalloprotease ACE and NEP dual inhibitor (Ki: 0.64 and 0.45 nM, respectively). Target: RAAS. Smiles: [H][C@]12CCC[C@H](N1C(=O)[C@H](CCS2)NC(=O)[C@@H](S)Cc1ccccc1)C(O)=O. References: Fryer RM, et al. Effect of bradykinin metabolism inhibitors on evoked hypotension in rats: rank...

Omapatrilat is an orally bioavailable angiotensin-converting enzyme (ACE) and neprilysin (NEP) inhibitior (IC50s = 1.7 and 5.3 nM, respectively, for the human enzymes). It inhibits the pressor response induced by angiotensin I (Cay-24737) in normotensive rats (ED50 = 0.07 µmol/kg) and lowers mean arterial pressure...