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Belzutifan
Item number: Cay39652-1
Belzutifan is an inhibitor of hypoxia-inducible factor-2alpha (HIF-2alpha). It inhibits HIF-2alpha heterodimerization with the aryl hydrocarbon receptor nuclear translocator (ARNT) PAS-B domain in a cell-free assay (Ki = 23 nM), activation of HIF-2alpha in a reporter assay using 786-O renal cell carcinoma cells...
| Keywords: | MK-6482, PT2977,... |
| Application: | HIF-2alpha inhibitor |
| CAS | 1672668-24-4 |
| MW: | 383.3 D |
From 49.00€
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Belzutifan
Item number: TGM-T16679-1mg
Description: Belzutifan (MK-6482) is a potential treatment for clear cell renal cell carcinoma (ccRCC). Belzutifan is an orally active and selective HIF-2alpha inhibitor (IC50: 9 nM). Belzutifan , as a second-generation HIF-2alpha inhibitor, increases potency and improves pharmacokinetic profile. Target: HIF....
| Keywords: | MK-6482, PT2977 |
| Application: | Targets hypoxia-inducible factor 2 alpha (HIF2A, EPAS1) |
| CAS | 1672668-24-4 |
| MW: | 383.34 D |
From 60.00€
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