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Item number: Cay27911-10

TAS 6417 is a pan-EGFR inhibitor. It inhibits wild-type EGFR (IC50= 8 nM), as well as the EGFR point mutants EGFRL858R, EGFRL861Q, EGFRT790M, EGFRT790M/L858R (IC50s = 1.9, 5.5, 4.1, and 2 nM, respectively) and the insertion or deletion mutants EGFR D770_N771insNPG, EGFR d746-750, and EGFR d746-770/T790M (IC50s =...

Keywords:	CLN-081, Zipalertinib, N-[(8S)-4-amino-8,9-dihydro-6-methyl-5-(3-quinolinyl)pyrimido[5,4-b]indolizin-8-yl]-2-propenamide
Application:	Pan-EGFR inhibitor
CAS	1661854-97-2
MW:	396.4 D

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