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Item number: Cay41833-1

LNP023 is a complement factor B (CFB) inhibitor (IC50 = 10 nM). It is selective for CFB over a panel of 41 proteases and 110 other enzymes, receptors, and ion channels (IC50s = >30 µM for all). LNP023 inhibits formation of the membrane attack complex induced by zymosan A (Cay-21175) in isolated human whole blood...

Keywords:	Iptacopan, 4-[(2S,4S)-4-ethoxy-1-[(5-methoxy-7-methyl-1H-indol-4-yl)methyl]-2-piperidinyl]-benzoic acid
Application:	Complement factor B (CFB) inhibitor
CAS	1644670-37-0
MW:	422.5 D

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Iptacopan

Item number: TGM-T11864-100mg

Description: Iptacopan (LNP023) is an inhibitor with high affinity for factor B. Target: Others. Smiles: CCO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O. References: Schubart A, et al. Small-molecule factor B inhibitor for the treatment of complement-mediated diseases. Proc Natl Acad Sci U S A. 2019...

Keywords:	LNP023
Application:	Targets complement factor B [EC:3.4.21.47] (CFB)
CAS	1644670-37-0
MW:	422.52 D

From 131.00€ *

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