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Eltanexor
Item number: Cay43585-1
Eltanexor is an inhibitor of exportin 1 (XPO1/CRM1). It inhibits the binding of XPO1/CRM1 to various nuclear export signals (NESs) in cell-free pull-down assays when used at a concentration of 10 µM. Eltanexor inhibits Cas9-encoding mRNA nuclear export in HEK293T cells in a concentration-dependent manner and...
| Keywords: | KPT-8602, alphaE-[[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]methylene]-5-pyrimidineacetamide |
| Application: | XPO1/CRM1 inhibitor |
| CAS | 1642300-52-4 |
| MW: | 428.3 D |
From 88.00€
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Eltanexor
Item number: TGM-T11766L-100mg
Description: Eltanexor (ONO-7706) is an orally active exportin-1 (XPO1) inhibitor. It has effective anti-leukemic activity. Eltanexor inhibits XPO1-dependent nuclear export (EC50=60.9 nM) by directly targeting XPO1. Eltanexor causes caspase-dependent apoptosis in a panel of leukemic cell lines. Target: Others....
| Keywords: | ATG-016, KPT-8602, ONO-7706 |
| Application: | Targets exportin-1 (XPO1, CRM1) |
| CAS | 1642300-52-4 |
| MW: | 428.29 D |
From 57.00€
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