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Item number: Cay31755-1

SAGE-217 is a positive allosteric modulator of GABAA receptors. It potentiates GABA-induced currents in LTK cells expressing alpha4beta2gamma2 subunit-containing GABAA receptors and CHO cells expressing alpha4beta3delta subunit-containing GABAA receptors (EC50s = 375 and 299 nM, respectively). SAGE-217 (0.3-10...

Keywords:	S-812217, SGE 797, 1-[(3alpha,5beta)-3-hydroxy-3-methyl-20-oxo-19-norpregnan-21-yl]-1H-pyrazole-4-carbonitrile
Application:	Positive allosteric GABA(A) receptor modulator
CAS	1632051-40-1
MW:	409.56 D

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