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Item number: Cay45386-1

An inhibitor of Nav1.7 (IC50 = 0.003 µM), selective for Nav1.7 over Nav1.1, Nav1.2, Nav1.5, and Nav1.6 (IC50s = 0.045, 0.007, 0.110, and 0.092 µM, respectively), reduces aconitine-induced nocifensive behavior in a transgenic mouse model of IEM at 30 mg/kg. SMILES:...

Keywords:	N-[6-cyclopropyl-7-(tricyclo[3.3.1.13,7]dec-1-ylmethoxy)-1,2,4-triazolo[4,3-a]pyridin-3-yl]-cyclopropanesulfonamide
Application:	Nav1.7 (SCN9A) inhibitor
CAS	1629063-81-5
MW:	442.58 D

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GNE-131

Item number: TGM-TQ0014-1mg

Description: GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM). Target: Sodium Channel. Smiles: O=S(=O)(Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1)C1CC1. References: Focken T, et al. Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of...

CAS	1629063-81-5
MW:	442.57 D

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