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Item number: Cay25498-5

GLP1690 is a potent inhibitor of autotaxin (Ki = 15 nM). It inhibits the production of lysophosphatidic acid (LPA) in mouse, rat, and human plasma (IC50s = 418, 542, and 242 nM, respectively). GLPG1690 (30 mg/kg) reduces extracellular matrix deposition in the lung as well as LPA 18:2 levels in bronchoalveolar lavage...

Keywords:	2-[[2-ethyl-6-[4-[2-(3-hydroxy-1-azetidinyl)-2-oxoethyl]-1-piperazinyl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-...
Application:	Potent autotaxin inhibitor
CAS	1628260-79-6
MW:	588.7 D

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Ziritaxestat

Item number: TGM-T4041-100mg

Description: Ziritaxestat (GLPG1690), an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients. Target: PDE. Smiles: CCc1nc2c(C)cc(cn2c1CNc1nc(c(s1)C#N)-c1ccc(F)cc1)N1CCN(CC(=O)N2CC(O)C2)CC1. References: Desroy N., et al. Discovery of...

Keywords:	GLPG1690
Application:	Targets ectonucleotide pyrophosphatase/phosphodiesterase family member 2 [EC:3.1.4.39] (ENPP2)
CAS	1628260-79-6
MW:	588.7 D

From 41.00€ *

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