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Item number: Cay44231-10

Lerociclib is an inhibitor of cyclin-dependent kinase 4 (Cdk4) and Cdk6 (IC50s = 1 and 2 nM for Cdk4/cyclin D1 and Cdk6/cyclin D3, respectively). It is selective for Cdk4 and Cdk6 over seven related Cdks, including Cdk9/cyclin T, Cdk5/p25, and Cdk1/cyclin B1 (IC50s = 28, 1,200, and 2,400 nM, respectively)....

Keywords:	G1T38
Application:	Antineoplastic, cyclin-dependent kinase (Cdk4/Cdk6) inhibitor
CAS	1628256-23-4
MW:	474.61 D

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Lerociclib

Item number: TGM-T11345-5mg

Description: Lerociclib (G1T38) is a potent and selective inhibitor of CDK4/6, with IC50 values of 2 nM for CDK6/CyclinD3 and 1 nM for CDK4/CyclinD1. Target: CDK. Smiles: O=C1C=2N(C3(CN1)CCCCC3)C=4C(C2)=CN=C(NC5=CC=C(C=N5)N6CCN(C(C)C)CC6)N4. References: Bisi JE, et al. Preclinical development of G1T38: A novel,...

Keywords:	G1T38
CAS	1628256-23-4
MW:	474.6 D

73.00€ *

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