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TL4-12
Item number: Cay42907-1
TL4-12 is an inhibitor of MAP4K2 (IC50 = 37. nM). It is selective for MAP4K2 over 20 other kinases at 1 µM. TL4-12 (500 nM) inhibits IL-1alpha- or TGF-beta-induced increases in p38 phosphorylation in primary mouse embryonic fibroblasts. It induces apoptosis in MM.1S multiple myeloma cells when used at concentrations...
| Keywords: | 4-methyl-3-[[6-(methylamino)-4-pyrimidinyl]oxy]-N-[3-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)phenyl]-benzamide |
| Application: | MAP4K2 inhibitor |
| CAS | 1620820-12-3 |
| MW: | 500.53 D |
From 47.00€
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TL4-12
Item number: TGM-T26280-100mg
Description: TL4-12 is a specific MAP4K2/GCK inhibitor that inhibits IKZF1 and BCL-6.TL4-12 inhibits MM cell proliferation and induces apoptosis, and can be used in the study of multiple myeloma (MM). Target: Apoptosis, Bcl-2 Family, Immunology/Inflammation related, IKZF, Bcl-6, MAPK. Smiles:...
| Keywords: | TL4 12 , TL412 |
| CAS | 1620820-12-3 |
| MW: | 500.52 D |
From 86.00€
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