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GNE-8505
Item number: Cay44006-1
GNE-8505 is an inhibitor of dual leucine zipper kinase (DLK). It decreases the levels of phosphorylated JNK in retinal lysates prepared from a mouse model of optic nerve crush when administered at doses of 3, 7, or 18 mg/kg. InChI:...
| Keywords: | 5-[1-(cyclopropylmethyl)-5-[(1alpha,5alpha,6alpha)-3-(3-oxetanyl)-3-azabicyclo[3.1.0]hex-6-yl]-1H-pyrazol-3-yl]-3-(trifluo... |
| Application: | Dual leucine zipper bearing kinase (DLK) inhibitor |
| CAS | 1620573-48-9 |
| MW: | 419.4 D |
From 115.00€
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GNE-8505
Item number: TGM-T11440-100mg
Description: GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK). Target: DNA Alkylation. Smiles: C(N1C([C@@H]2[C@@]3([C@]2(CN(C3)C4COC4)[H])[H])=CC(=N1)C=5C=C(C(F)(F)F)C(N)=NC5)C6CC6. References: Le Pichon CE, et al. Loss of dual leucine zipper kinase signaling is protective in animal...
| CAS | 1620573-48-9 |
| MW: | 419.44 D |
From 871.00€
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