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Item number: Cay16400-5

SET domain-containing protein 8 (SET8) is a methyltransferase that selectively mono-methylates histone H4 at lysine residue 20, an event proven to have an important role in chromatin structure and transcriptional activation. It is also a regulator of p53, mono-methylating lysine 382 of the tumor suppressor. UNC0379...

Keywords:	6,7-dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-4-quinazolinamine
Application:	SET8 inhibitor
CAS	1620401-82-2
MW:	413.6 D

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UNC0379

Item number: TGM-T1841-100mg

Description: UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase (SETD8). Target: Histone Methyltransferase. Smiles: COc1cc2nc(nc(NCCCCCN3CCCC3)c2cc1OC)N1CCCC1. References: Ma A, et al. J Med Chem. 2014, 57(15), 6822-6833.

Application:	SET8 inhibitor
CAS	1620401-82-2
MW:	413.56 D

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