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Item number: Cay15341-10

Talampanel is an allosteric AMPA receptor antagonist (IC50 = 2.5 µM in cerebellar Purkinje neurons using voltage-clamp electrophysiology). It reduces the firing rate of spinal neurons in rats by 68% when administered at a dose of 10 mg/kg following AMPA administration. It is protective against seizures in mouse...

Keywords:	GYKI 53773, LY 300164, (8R)-7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine
Application:	Allosteric AMPA receptor antagonist
CAS	161832-65-1
MW:	337.4 D

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Talampanel

Item number: TGM-T16977-10mg

Description: Talampanel (LY-300164) is an orally and selective alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist with anti-seizure activity. Talampanel (IVAX) has neuroprotective effects in rodent stroke models. Target: Apoptosis, GluR. Smiles: C[C@@H]1Cc2cc3OCOc3cc2C(=NN1C(C)=O)c1ccc(N)cc1....

Keywords:	GYKI-53773, LY-300164
Application:	Antiepileptic, AMPA receptor antagonist
CAS	161832-65-1
MW:	337.37 D

From 31.00€ *

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