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Item number: TGM-T7001-100mg

Description: TIC10 (ONC-201) inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2. Target: Apoptosis, TNF. Smiles: Cc1ccccc1CN1C2=NCCN2C2=C(CN(Cc3ccccc3)CC2)C1=O. References:...

Keywords:	ONC-201
Application:	Targets dopamine receptor D2 (DRD2)
CAS	1616632-77-9
MW:	386.49 D

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TIC10

Item number: Cay16109-5

TIC10 induces the expression of TNF-related apoptosis-inducing ligand (TRAIL) at 1-5 µM in a p53-independent manner. It is orally active, stable, and crosses the blood-brain barrier. The induction of TRAIL results from dual inhibition of Akt and ERK1/2 combined with nuclear translocation of the transcription factor...

Keywords:	ONC201, 2,4,6,7,8,9-hexahydro-4-[(2-methylphenyl)methyl]-7-(phenylmethyl)-imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one
Application:	TRAIL expression inducer
CAS	1616632-77-9
MW:	386.5 D

From 44.00€ *

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