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Item number: Cay18354-1

GSK591 is a chemical probe for protein arginine methyltransferase 5 (PRMT5) that potently inhibits the PRMT5/MEP50 complex from methylating histone H4 (IC50 = 11 nM) in vitro. GSK591 is selective for PRMT5 (up to 50 µM) relative to a panel of other methyltransferases. In Z-138 cells, GSK591 inhibits the symmetric...

Keywords:	EPZ015866, GSK3203591, 2-(cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-4-pyridinecarboxamide
Application:	PRMT5 chemical probe, PRMT5/MEP50 complex inhibitor
CAS	1616391-87-7
MW:	380.5 D

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GSK591

Item number: TGM-T6853-100mg

Description: GSK591 (GSK3203591), Alternative Names are EPZ015866, GSK3203591, is a potent selective inhibitor of the arginine methyltransferase PRMT5 (IC50=11 nM). Target: Histone Methyltransferase. Smiles: O[C@@H](CNC(=O)c1ccnc(NC2CCC2)c1)CN1CCc2ccccc2C1. References: SGC. GSK591 A chemical probe for PRMT5.

Keywords:	GSK3203591 , EPZ015866
Application:	PRMT5 chemical probe, PRMT5/MEP50 complex inhibitor
CAS	1616391-87-7
MW:	380.48 D

From 39.00€ *

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