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ARN-3236
Item number: TGM-T5993-100mg
Description: ARN-3236 is an orally active and selective inhibitor of salt-inducible kinase 2 (SIK2), with IC50 values of <1 nM for SIK2, 21.63 nM for SIK1, and 6.63 nM for SIK3. ARN-3236 exhibits anti-cancer activity. Target: AMPK, SIK. Smiles: COc1ccc(-c2c[nH]c3nccc(-c4ccsc4)c23)c(OC)c1. References: Zhou J ,...
| Application: | SIK2 inhibitor |
| CAS | 1613710-01-2 |
| MW: | 336.41 D |
From 55.00€
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ARN3236
Item number: Cay31457-1
ARN3236 is an inhibitor of salt-inducible kinase 2 (SIK2, IC50 = 50s = 21.63 and 6.63 nM, respectively). It inhibits TNF-alpha secretion in RAW 264.7 cells (IC50 = ~2.5 µM) and reduces phosphorylation of the SIK2 targets CRTC3 and HDAC4 in macrophages when used at a concentration of 3 µM. ARN3236 inhibits growth of...
| Keywords: | 3-(2,4-dimethoxyphenyl)-4-(3-thienyl)-1H-pyrrolo[2,3-b]pyridine |
| Application: | SIK2 inhibitor |
| CAS | 1613710-01-2 |
| MW: | 336.4 D |
From 61.00€
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