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Item number: Cay31754-5

Alofanib is an allosteric inhibitor of FGFR2. It inhibits FGF2-induced phosphorylation of FGFR substrate 2 (FRS2alpha) in KATO III gastric carcinoma cells (IC50 = 50s = 370 and 210 nM, respectively). It inhibits proliferation of human umbilical vein endothelial cells (HUVECs) induced by basic FGF (bFGF, IC50 = 11...

Keywords:	RPT835, 3-[[[4-methyl-2-nitro-5-(3-pyridinyl)phenyl]amino]sulfonyl]-benzoic acid
Application:	Allosteric FGFR2 inhibitor
CAS	1612888-66-0
MW:	413.4 D

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Alofanib

Item number: TGM-T5122-100mg

Description: Alofanib (RPT835) is a selective allosteric inhibitor of FGFR2 and has a dramatic inhibitory effect on FGF2-induced phosphorylation of FRS2a in KATO III cells (IC50 <10 nM). It has no direct effect on FGF2-dependent FGFR1 and FGFR3 phosphorylation levels in either cell lines and no effects on FGF2-FGFR2...

Keywords:	RPT835
Application:	Allosteric FGFR2 inhibitor
CAS	1612888-66-0
MW:	413.4 D

From 30.00€ *

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