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Item number: Cay18132-1

Human mutT homolog (MTH1) is a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (dNTPs) to prevent incorporation of damaged bases during DNA replication. Cancer cells rely on MTH1 activity in order to avoid cell death. TH287 is an MTH1 inhibitor (IC50 = 0.8 nM) that selectively kills cancer cell...

Keywords:	6-(2,3-dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine
Application:	MTH1 inhibitor
CAS	1609960-30-6
MW:	269.1 D

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TH287

Item number: TGM-T2069-100mg

Description: TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16. Target: DNA/RNA Synthesis, MTH1. Smiles: CNc1cc(nc(N)n1)-c1cccc(Cl)c1Cl. References: Gad H, et al. Nature. 2014, 508(7495), 215-221.

Keywords:	TH287 hydrochloride
CAS	1609960-30-6
MW:	269.13 D

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