Melagatran is an inhibitor of thrombin (Ki = 0. µM) and an active metabolite of the prodrug ximelagatran (Cay-16862). It is selective for thrombin over a variety of serine proteases (Kis = 0.6-10. µM) but also inhibits trypsin (Ki = 0. µM). Melagatran inhibits thrombin-induced aggregation of isolated washed human...

Description: Melagatran, a direct and orally active thrombin inhibitor, specifically inhibits thrombin without affecting other enzymes in the coagulation cascade or fibrinolytic enzymes. It does not rely on endogenous co-factors to exert its antithrombin effect, and may alleviate the harmful effects of endotoxemia....