10 products were found matching "159351-69-6"!

The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that, as part of two distinct complexes (mTORC1 and mTORC2), plays pivotal roles in intracellular signaling. Everolimus is a hydroxyethyl ether rapamycin (Cay-13346) derivative that inhibits mTOR signaling through both mTORC1 and mTORC2 when added...

Everolimus is an immunosuppressant analog of rapamycin (sirolimus) and inhibits growth factor-mediated proliferation of hematopoietic and nonhematopoietic cells. Everolimus shows a potent inhibitory effect on posttransplant lymphoproliferative disorder (PTLD)-derived cells in vitro and in vivo, in a dose range that...

White to off-white solid. Soluble in DMSO (50mg/ml), ethanol (50mg/ml), methanol or DMF. Insoluble in water. Chemical. CAS: 159351-69-6. Formula: C53H83NO14. MW: 958.2. Isolated from Streptomyces hygroscopicus. Macrolide antibiotic, inhibiting bacterial protein synthesis. Orally available Rapamycin derivative that...

Soluble in DMSO at 100 mg/mL, soluble in ethanol at 100 mg/mL, very poorly soluble in water, maximum solubility in plain water is estimated to be about 1-10 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility

White to off-white solid. Soluble in DMSO (50mg/ml), ethanol (50mg/ml), methanol or DMF. Insoluble in water. Chemical. CAS: 159351-69-6. Formula: C53H83NO14. MW: 958.2. Isolated from Streptomyces hygroscopicus. Macrolide antibiotic, inhibiting bacterial protein synthesis. Potent immunosuppressant. Binds with high...

Liquid. Chemical. CAS: 159351-69-6. Formula: C53H83NO14. MW: 958.22. Macrolide antibiotic, inhibiting bacterial protein synthesis. Potent immunosuppressant. Binds with high affinity to the FK506 binding protein-12 (FKBP-12) to generate an immunosuppressive complex that inhibits the activation of the mammalian...

Isotope Incorporation: >98%