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TP0463518
Item number: TGM-T5392-5mg
Description: TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 nM for human and rat PHD2, respectively). Target: HIF/HIF Prolyl-Hydroxylase. Smiles: OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(Cl)cc3)nc2)C1=O. References: Kato S, et al. TP0463518, a novel inhibitor for...
| Application: | Pan HIF-PH inhibitor |
| CAS | 1558021-37-6 |
| MW: | 431.83 D |
From 46.00€
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TP-0463518
Item number: Cay33788-10
TP-0463518 is a pan hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor. It inhibits human HIF-PH1 (Ki = 5.3 nM), as well as human HIF-PH2 and HIF-PH3 (IC50s = 18 and 63 nM, respectively). TP-0463518 (5 mg/kg) increases serum levels of erythropoietin (EPO) in mice. It also increases serum EPO levels in a...
| Keywords: | N-[[1-[[6-(4-chlorophenoxy)-3-pyridinyl]methyl]-1,2,5,6-tetrahydro-4-hydroxy-2-oxo-3-pyridinyl]carbonyl]-glycine |
| Application: | Pan HIF-PH inhibitor |
| CAS | 1558021-37-6 |
| MW: | 431.8 D |
From 66.00€
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