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GSK 199 (hydrochloride)
Item number: Cay17489-5
GSK 199 is an inhibitor of peptidyl arginine deiminase 4 (PAD4, IC50 = 200 nM in the absence of calcium). It selectively inhibits the production of citrulline by PAD4 over PAD1, PAD2, and PAD3 in kinetic assays. GSK 199 (10 µM) prevents histone H3 citrullination and neutrophil extracellular trap (NET) formation...
| Keywords: | [(3R)-3-amino-1-piperidinyl][2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzimidazol-5-yl]-methanone,... |
| Application: | Reversible PADI4 inhibitor |
| CAS | 1549811-53-1 |
| MW: | 469 D |
From 108.00€
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GSK199
Item number: TGM-T8861-100mg
Description: GSK199 is a selective PAD4 inhibitor(IC50 of 200 nM in the absence of calcium). Target: PAD. Smiles: Cl.CCn1c(cc2cccnc12)-c1nc2cc(cc(OC)c2n1C)C(=O)N1CCC[C@@H](N)C1. References: Willis V C , Banda N K , Cordova K N , et al. Protein arginine deiminase 4 inhibition is sufficient for the amelioration of...
| Application: | Reversible PADI4 inhibitor |
| CAS | 1549811-53-1 |
| MW: | 468.98 D |
From 98.00€
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