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SP100030
Item number: Cay42898-10
SP100030 is an inhibitor of gene transcription mediated by NF-kappaB and activator protein-1 (AP-1). It inhibits NF-kappaB- and AP-1-mediated transcription in a reporter assay using Jurkat T cells (IC50 = 0. µM for both) and decreases IL-2 and IL-8 levels in Jurkat T cells (IC50 = 0. µM for both). SP100030 (20 mg/kg...
| Keywords: | N-[3,5-bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide |
| Application: | NF-kappaB- / AP-1-mediated gene transcription inhibitor |
| CAS | 154563-54-9 |
| MW: | 437.7 D |
From 89.00€
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SP-100030
Item number: TGM-T24816-100mg
Description: SP-100030 is a dual inhibitor of NF-kappaB and activator protein-1 (AP-1), demonstrating potent inhibition with IC50 values of 50 nM for both. It effectively reduces the production of IL-2, IL-8, and TNF-alpha in Jurkat and other T cell lines. Additionally, SP-100030 has been shown to decrease the...
| Keywords: | SP100030, SP 100030 |
| CAS | 154563-54-9 |
| MW: | 437.65 D |
From 30.00€
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