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CB-5083
Item number: TGM-T6796-100mg
Description: CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM). Target: p97. Smiles: Cc1cc2c(cccc2n1-c1nc2CCOCc2c(NCc2ccccc2)n1)C(N)=O. References: Zhou HJ, et al. J Med Chem. 2015, 58(24), 9480-9497.
| Keywords: | CB5083, CB 5083 |
| Application: | p97 inhibitor |
| CAS | 1542705-92-9 |
| MW: | 413.47 D |
From 40.00€
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CB-5083
Item number: Cay19311-1
CB-5083 is an orally bioavailable inhibitor of p97 (IC50 = 11 nM), a transitional endoplasmic reticulum ATPase also known as valosin-containing protein (VCP). It disrupts cellular protein homeostasis and demonstrates anti-tumor activity in hematological and solid tumor models. CB-5083 causes accumulation of...
| Keywords: | 1-[7,8-dihydro-4-[(phenylmethyl)amino]-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide |
| Application: | p97 inhibitor |
| CAS | 1542705-92-9 |
| MW: | 413.5 D |
From 61.00€
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