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Item number: Cay25979-1

Cilomilast is a second generation inhibitor of phosphodiesterase 4 (PDE4, IC50 = 0.12 µM for the human enzyme). It is selective for human PDE4 over bovine PDE1, rat PDE2, and human PDE3 and -5 (IC50s = 74, 65, >100, and 83 µM, respectively). Cilomilast inhibits LPS-induced production of TNF-alpha in isolated human...

Keywords:	SB 207499, cis-4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-cyclohexanecarboxylic acid
Application:	PDE4 inhibitor
CAS	153259-65-5
MW:	343.4 D

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