3 products were found matching "1527473-33-1"!
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PF-06447475
Item number: Cay18375-10
PF-06447475 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 = 3 nM), an enzyme genetically linked to Parkinson's disease that interacts with parkin, a ligase whose loss of function leads to dopaminergic cell death. PF-06447475 has been shown to attenuate alpha-synuclein-induced dopaminergic...
| Keywords: | 3-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-benzonitrile |
| Application: | LRRK2 inhibitor |
| CAS | 1527473-33-1 |
| MW: | 305.3 D |
From 53.00€
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PF-06447475
Item number: LKT-P2100.25
LRRK2 inhibitor.
| Application: | LRRK2 inhibitor |
| CAS | 1527473-33-1 |
| MW: | 305.13 D |
From 152.00€
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PF-06447475
Item number: TGM-T2050-100mg
Description: PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively. Target: LRRK2. Smiles: N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12. References: Henderson JL, et al. J Med Chem. 2015, 58(1), 419-432.
| Application: | LRRK2 inhibitor |
| CAS | 1527473-33-1 |
| MW: | 305.33 D |
From 41.00€
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