MS049 is a potent and selective inhibitor of protein arginine methyltransferase 4 (PRMT4, IC50 = 34 nM) and PRMT6 (IC50 = 43 nM). It is less active against additional type I PRMTs (IC50s = >13, >22, and 1. µM for PRMT1, PRMT3, and PRMT8, respectively) and displays no inhibition against type II or type III PRMTs nor...

Description: MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively. Target: Histone Methyltransferase. Smiles: CNCCN1CCC(CC1)OCc1ccccc1. References: Shen Y,etal.Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine...