Brusatol is a quassinoid that has been found in B. javanica and has diverse biological activities, including antimalarial, lipolytic, antioxidative, anticancer, and anti-inflammatory properties. It is active against chloroquine-resistant isolates of P. falciparum (EC50 = 7.58 ng/ml) and induces lipolysis in 3T3-L1...

Description: Brusatol (NSC-172924) is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2. Target: Apoptosis, Ferroptosis, Nrf2. Smiles: COC(=O)[C@]12OC[C@@]34[C@H]1[C@@H](OC(=O)C=C(C)C)C(=O)O[C@@H]3C[C@H]1C(C)=C(O)C(=O)C[C@]1(C)[C@H]4[C@@H](O)[C@@H]2O. References: Wang Y, Ma H, Huang J, et...