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Item number: Cay43933-10

KRCA 0008 is an inhibitor of anaplastic lymphoma kinase (ALK) and tyrosine non-receptor kinase 2 (TNK2), also known as activated Cdc42 kinase 1 (ACK1, IC50s = 12 and 4 nM, respectively). It is selective for these kinases over the insulin receptor (InsR, IC50 = 210 nM). KRCA 0008 also inhibits the ALK mutants...

Keywords:	1-phenylene)-4,1-piperazinediyl]]bis-1,1'-[(5-chloro-2,4-pyrimidinediyl)bis[imino(3-methoxy-4 ethanone
Application:	ALK / TNK2 inhibitor
CAS	1472795-20-2
MW:	609,13 D

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KRCA-0008

Item number: TGM-T2641-100mg

Description: KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM), displays drug-like properties without hERG liability. Target: ACK, ALK. Smiles: COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccc(cc2OC)N2CCN(CC2)C(C)=O)n1)N1CCN(CC1)C(C)=O. References: Park CH, et al. Bioorg Med Chem Lett. 2013 Nov 15,23(22):6192-6.

Keywords:	KRCA 0008, KRCA0008
CAS	1472795-20-2
MW:	609.12 D

From 38.00€ *

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