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Item number: Cay42906-1

AMG 2850 is an antagonist of transient receptor potential melastatin 8 (TRPM8). It inhibits menthol- or cold-induced intracellular calcium release in CHO cells expressing rat TRPM8 (IC50s = 7. and 150 nM, respectively). AMG 2850 is selective for TRPM8 over transient receptor potential ankyrin 1 (TRPA1), transient...

Keywords:	5,8R-dihydro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-8-[4-(trifluoromethyl)phenyl]-1,7-naphthyridine-7(6H)-carboxamide
Application:	TRPM8 antagonist
CAS	1470018-52-0
MW:	417.36 D

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AMG2850

Item number: TGM-T10300-100mg

Description: AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 [TRPM8]. Target: TRP/TRPV Channel. Smiles: C[C@H](NC(=O)N1CCc2cccnc2[C@H]1c1ccc(cc1)C(F)(F)F)C(F)(F)F. References: Lehto SG, et al. AMG2850, a potent and selective TRPM8 antagonist, is not...

CAS	1470018-52-0
MW:	417.35 D

From 65.00€ *

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Review

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