Description: Y-27632 is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells. Target: Apoptosis, ROCK. Smiles: C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1. References: Wu Y, et al. ROCK inhibitor Y27632...

Y-27632 (also called Y27632 or Y 27632) is a potent, cell permeable, selective and ATP-competitive Rho-associated protein kinases inhibitor, including p160ROCK, ROCK-II and PRK2 inhibitor. Ki values are 0.14, 26, 25 and >250uM for p160ROCK, PKC, cAMP-dependent protein kinase and myosin light-chain kinase,...