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Item number: TGM-T6837-10mg

Description: Flavopiridol (Alvocidib) (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1, 2, 4, 6 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Phase 1/2. Target: CDK, HIV Protease, Apoptosis,...

Keywords:	HMR-1275, L868275, Alvocidib, NSC 649890 HCl
Application:	Targets cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23] (CDK1, CDC2)
CAS	146426-40-6
MW:	401.84 D

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Flavopiridol

Item number: Cay26024-5

Flavopiridol is an orally bioavailable inhibitor of cyclin dependent kinases (IC50s = ~100, ~100, ~100, and 300 nM for Cdk1, Cdk2, Cdk4, and Cdk7, respectively). It also inhibits TEFb, a complex composed of Cdk9 and cyclin T1, with a Ki value of 3 nM. Flavopiridol inhibits transcription of a CMV promoter in HeLa...

Keywords:	Alvocidib, HL 275, HMR 1275, L-868,275,...
Application:	Cyclin dependent kinase inhibitor
CAS	146426-40-6
MW:	401.8 D

From 78.00€ *

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