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M2912
Item number: Cay45586-1
M2912 is an inhibitor of tankyrase 1 (TNKS1) and TNKS2 (IC50s = 0.6 and 0.9 nM, respectively). It is selective for TNKS1 and TNKS2 over poly(ADP-ribose) polymerase 1 (PARP1, IC50 = 928 nM). M2912 increases the levels of Axin2 (EC50 = 17 nM) and reduces Wnt reporter activity in DLD-1 cells. It reduces the growth of a...
| Keywords: | MSC2504877, 3-[4-(1-hydroxy-1-methylethyl)phenyl]-6-methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one |
| Application: | TNKS1/2 inhibitor |
| CAS | 1460286-21-8 |
| MW: | 282.34 D |
From 49.00€
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NEW
MSC2504877
Item number: TGM-T60098-10mg
Description: MSC2504877 is an inhibitor of tankyrase and enhances the effects of clinical CDK4/6 inhibitors. MSC2504877 suppresses the upregulation of Cyclin D2 and Cyclin E2 caused by palbociclib and enhances the suppression of phospho-Rb. Target: Others. Smiles: Cc1ccc2n1cc([nH]c2=O)-c1ccc(cc1)C(C)(C)O....
| Keywords: | 3-(4-(2-Hydroxypropan-2-yl)phenyl)-6-methylpyrrolo[1,2-a]pyrazin-1(2H)-one |
| CAS | 1460286-21-8 |
| MW: | 282.34 D |
From 38.00€
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