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SLP7111228 (hydrochloride)
Item number: Cay23290-10
SLP7111228 is a potent and selective inhibitor of sphingosine kinase (SPHK) 1 with Ki values of 0.048 and >10 µM for SPHK1 and 2, respectively. It induces a concentration-dependent decrease in sphingosine-1-phosphate (S1P, Cay-62570) in U937 cells but has no effect on sphingosine levels. In vivo, SLP7111228...
| Keywords: | (2S)-2-[[3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl]methyl]-1-pyrrolidinecarboximidamide, monohydrochloride |
| Application: | SPHK1 inhibitor |
| CAS | 1449768-48-2 |
| MW: | 420 D |
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SLP7111228 hydrochloride
Item number: TGM-T85280-10mg
Description: SLP7111228 is a potent, selective SPHK1 inhibitor with Ki values of 0.048 µM for SPHK1 and >10 µM for SPH2K, showing a concentration-dependent reduction of sphingosine-1-phosphate (S1P) in U937 cells without affecting sphingosine levels. In vivo, it dose-dependently lowers S1P blood levels in rats....
| Application: | SPHK1 inhibitor |
| CAS | 1449768-48-2 |
| MW: | 420 D |
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