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RO9021
Item number: TGM-T16776-100mg
Description: RO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor [average IC50: 5.6 nM]. Target: Syk. Smiles: Cc1ccc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)nc1C. References: Liao C, et al. Selective inhibition of spleen tyrosine kinase (SYK) with a novel orally bioavailable small molecule inhibitor,...
| Application: | Syk inhibitor |
| CAS | 1446790-62-0 |
| MW: | 355.44 D |
From 79.00€
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RO9021
Item number: Cay37543-10
RO9021 is an inhibitor of spleen tyrosine kinase (Syk, IC50 = 5.6 nM). It is selective for Syk over a panel of 392 other kinases at 1 µM. RO9021 also inhibits M. tuberculosis serine/threonine protein kinase G (PknG, IC50 = 4.4 µM). It inhibits the proliferation of, and induces apoptosis in, primary acute myeloid...
| Keywords: | ChEMBL 3237561, 6-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[(5,6-dimethyl-2-pyridinyl)amino]-3-pyridazinecarboxamide |
| Application: | Syk inhibitor |
| CAS | 1446790-62-0 |
| MW: | 355.4 D |
From 96.00€
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