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Item number: TGM-T7581-100mg

Description: Voxelotor (GBT 440) is an inhibitor of sickle hemoglobin (HbS). Target: Others. Smiles: CC(C)n1nccc1-c1ncccc1COc1cccc(O)c1C=O. References: Impact of voxelotor (GBT440) on unconjugated bilirubin and jaundice in sickle cell disease[J]. Hematology Reports, 2018, 10(2).

Keywords:	GBT 440
Application:	Antianemic, Hemoglobin S polymerization inhibitor
CAS	1446321-46-5
MW:	337.37 D

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GBT-440

Item number: Cay23933-5

GBT-440 is a modulator of sickle hemoglobin (HbS) that binds covalently to the N-terminal valine of the alpha chain of HbS. In vitro, GBT-440 increases HbS affinity for oxygen (EC50s = 8.2 and 415 µM for purified HbS and whole blood from sickle cell anemia patients, respectively) and delays oxygen release from and...

Keywords:	Voxelotor, 2-hydroxy-6-[[2-[1-(1-methylethyl)-1H-pyrazol-5-yl]-3-pyridinyl]methoxy]-benzaldehyde
Application:	HbS modulator
CAS	1446321-46-5
MW:	337.4 D

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