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GBT-440
Item number: Cay23933-5
GBT-440 is a modulator of sickle hemoglobin (HbS) that binds covalently to the N-terminal valine of the alpha chain of HbS. In vitro, GBT-440 increases HbS affinity for oxygen (EC50s = 8.2 and 415 µM for purified HbS and whole blood from sickle cell anemia patients, respectively) and delays oxygen release from and...
| Keywords: | Voxelotor, 2-hydroxy-6-[[2-[1-(1-methylethyl)-1H-pyrazol-5-yl]-3-pyridinyl]methoxy]-benzaldehyde |
| Application: | HbS modulator |
| CAS | 1446321-46-5 |
| MW: | 337.4 D |
From 38.00€
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voxelotor
Item number: TGM-T7581-100mg
Description: Voxelotor (GBT 440) is a novel hemoglobin S (HbS) polymerization inhibitor primarily used for the treatment of sickle cell disease (SCD) and a cytochrome P450 3A4 inhibitor. Voxelotor targets and covalently binds to the N-terminal valine of the HbS alpha chain, thereby stabilizing sickle cell hemoglobin...
| Keywords: | GBT 440 |
| Application: | Antianemic, Hemoglobin S polymerization inhibitor |
| CAS | 1446321-46-5 |
| MW: | 337.37 D |
From 40.00€
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