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CE3F4
Item number: Cay17767-5
Exchange protein activated by cAMP (Epac) proteins mediate cAMP signaling independent of protein kinase A (PKA). CE3F4 is an uncompetitive inhibitor of Epac1 activity toward its effector Rap1 in vitro (IC50 = 23 µM) and in cells.. It has no effect on PKA activity. CE3F4 blocks Epac1-induced autophagy in...
| Keywords: | 5,7-dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde |
| Application: | Epac1 inhibitor |
| CAS | 143703-25-7 |
| MW: | 351 D |
From 116.00€
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CE3F4
Item number: TGM-T12616L-10mg
Description: CE3F4 is a selective antagonist of exchange protein directly activated by cAMP (Epac1, IC50s of 10.7 µM and 66 µM for Epac1 and Epac2(B), respectively). Target: cAMP. Smiles: CC1CCc2c(Br)c(F)c(Br)cc2N1C=O. References: Courilleau D, et al. The (R)-enantiomer of CE3F4 is a preferential inhibitor of human...
| Application: | Epac1 inhibitor |
| CAS | 143703-25-7 |
| MW: | 351.01 D |
From 45.00€
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