Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is an excellent target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. 3-AP is a ribonucleotide reductase inhibitor and iron chelator with antitumor activity. At 5 µM...

Description: 3-AP (Triapine) is a novel inhibitor of the M2 subunit of ribonucleotide reductase (RR). Target: DNA/RNA Synthesis. Smiles: NC(=S)N\N=C\c1ncccc1N. References: Martin LK, et al. A dose escalation and pharmacodynamic study of Triapine and radiation in patients with locally advanced pancreas cancer. Int J...