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XMD17-109
Item number: TGM-T1842-100mg
Description: XMD17-109 (ERK5-IN-1) is a new selective ERK-5 inhibitor (EC50: 4.2 uM, HEK293 cells). Target: ERK. Smiles: CCOc1cc(ccc1Nc1ncc2N(C)C(=O)c3ccccc3N(C3CCCC3)c2n1)C(=O)N1CCC(CC1)N1CCN(C)CC1. References: Denq X, et al. Eur J Med Chem. 2013, 70, 758-767.
| Keywords: | XMD17 109, ERK5-IN-1 |
| Application: | Selective ERK5 inhibitor |
| CAS | 1435488-37-1 |
| MW: | 638.8 D |
From 37.00€
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XMD17-109
Item number: Cay25448-5
XMD17-109 is a selective ERK5 inhibitor (IC50 = 0.162 µM in an enzyme assay). It is selective for ERK5 over a panel of more than 200 kinases, inhibiting only ERK5 with greater than 90% target occupancy at a concentration of 10 µM. XMD17-109 inhibits ERK5 phosphorylation (IC50 = 0.09 µM in HeLa cells) and decreases...
| Keywords: | ERK5-IN-1,... |
| Application: | Selective ERK5 inhibitor |
| CAS | 1435488-37-1 |
| MW: | 638.8 D |
From 45.00€
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