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Item number: Cay39677-10

GX-674 is a state-dependent inhibitor of voltage-gated sodium channel 1.7 (Nav1.7). It selectively inhibits Nav1.7 in HEK293 cells in a patch-clamp assay at -40 mV over -120 mV, voltages that correspond to steady-state inactivation and the resting closed state of the channel (IC50s = 0.1 and 240 nM, respectively)....

Keywords:	4-[2-(2-amino-1H-benzimidazol-6-yl)-4-chlorophenoxy]-2,5-difluoro-N-1,2,4-thiadiazol-5-yl-benzenesulfonamide
Application:	State-dependent Nav1.7 inhibitor
CAS	1432913-36-4
MW:	534.9 D

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