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Item number: TGM-T6749-100mg

Description: A-1331852 is a potent and selectiveBCL-XL inhibitor and may be useful in the treatment of cancer, immune and autoimmune diseases. Target: BCL. Smiles: Cc1c(cnn1CC12CC3CC(CC(C3)C1)C2)-c1ccc(nc1C(O)=O)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1. References: Leverson JD, et al. Sci Transl Med. 2015, 7(279):279ra40.

Application:	BCL-XL inhibitor
CAS	1430844-80-6
MW:	658.81 D

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A-1331852

Item number: Cay22963-1

A-1331852 is an orally bioavailable Bcl-xL inhibitor that selectively binds Bcl-xL over Bcl-2, Mcl-1, and Bcl-W (Kis = in vitro (EC50s = 6 and >5,000 nM, respectively). A-1331852 (25 mg/kg twice per day) inhibits tumor growth in a MOLT-4 mouse xenograft model. It also inhibits tumor growth and increases the...

Keywords:	6-[8-[(2-benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)...
Application:	BCL-XL inhibitor
CAS	1430844-80-6
MW:	658.8 D

From 133.00€ *

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