Description: Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 µM) but no effect on SIRT3 even at 200 µM. Target: Sirtuin. Smiles: CCCCCCCCCC CCCC(=S)NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccccc1. References: Jing H, et al. Cancer Cell. 2016, 29(3):297-310.

Thiomyristoyl (TM) is a potent and selective inhibitor of SIRT2 with IC50 values of 0.028, 98, >200, and >200 µM for SIRT2, SIRT1, SIRT3, and SIRT5-7, respectively. It inhibits acetyl-H3K9 peptide and NAD binding to SIRT2 and promotes c-Myc degradation in a dose-dependent manner. TM exhibits selective cytotoxicity...