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Item number: Cay34928-1

Soticlestat is an inhibitor of cholesterol 24-hydroxylase/CYP46A1 (IC50 = 0.0074 µM). It is selective for cholesterol 24-hydroxylase/CYP46A1 over the cytochrome P450 (CYP) isoforms CYP2C8, -2C9, -2D6, -3A4, -1A2, and 2C19 (IC50s = 62, 19, >100, 66, >100, and 14 µM, respectively). Soticlestat (0.02% in the diet)...

Keywords:	OV935, TAK-935, [2,4'-bipyridin]-3-yl[4-hydroxy-4-(phenylmethyl)-1-piperidinyl]-methanone
Application:	Cholesterol 24-hydroxylase/CYP46A1 inhibitor
CAS	1429505-03-2
MW:	373.4 D

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Soticlestat

Item number: TGM-T8937-100mg

Description: Soticlestat (OV935) is a potent, selective and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor. It has the potential for epilepsy syndromes research. Target: P450. Smiles: OC1(Cc2ccccc2)CCN(CC1)C(=O)c1cccnc1-c1ccncc1. References: Toshiya Nishi, et al. Soticlestat, a novel cholesterol...

Keywords:	TAK-935, OV935
Application:	Targets cholesterol 24-hydroxylase [EC:1.14.14.25] (CYP46A1)
CAS	1429505-03-2
MW:	373.45 D

From 57.00€ *

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