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Acalabrutinib
Acalabrutinib

Item number: Cay19899-1

Acalabrutinib is an irreversible inhibitor of Bruton's tyrosine kinase (BTK). It can dose-dependently inhibit B cell receptor signaling in primary chronic lymphocytic leukemia cells. In kinase-inhibition assays, acalabrutinib was more selective than ibrutinib (Cay-16274) for inhibiting BTK and did not inhibit EGFR,...
Keywords: ACP-196, 4-[8-amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinyl-benzamide
Application: BTK inhibitor
CAS 1420477-60-6
MW: 465.5 D
From 43.00€ *
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Acalabrutinib, Free Base
Acalabrutinib, Free Base

Item number: LC-A-7337_100mg

Soluble in DMSO. Acalabrutinib, also known as ACP-196, is an irreversible Bruton tyrosine kinase (BTK) inhibitor. It binds covalently to Cys481 with improved selectivity and in vivo target coverage. Acalabrutinib inhibited BTK with an IC50 of 3 nM and had improved target specificity over ibrutinib with 323-, 94-,...
Keywords: ACP196, ACP-196
Application: Antineoplastic, Bruton's tyrosine kinase (BTK) inhibitor
CAS 1420477-60-6
MW: 465.51 D
From 83.00€ *
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Acalabrutinib
Acalabrutinib

Item number: LKT-A081014.100

Keywords: ACP-196
Application: BTK inhibitor
CAS 1420477-60-6
MW: 465.52 D
From 153.00€ *
Review