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Item number: Cay28832-10

HDAC8-IN-1 is an inhibitor of histone deacetylase 8 (HDAC8, IC50 = 27.2 nM). It is selective for HDAC8 over HDAC1-3, -4, -6, -10, and -11 (IC50s = >3,000 nM for all). HDAC8-IN-1 is cytotoxic to A549, H1299, and CL1-5 lung cancer cells (IC50s = 7.9, 7.2, and 7 µM, respectively).Formal Name:...

Keywords:	MDK-7933, (2E)-N-hydroxy-3-(5-methoxy[1,1':4',1''-terphenyl]-2-yl)-2-propenamide
Application:	HDAC8 inhibitor
CAS	1417997-93-3
MW:	345.4 D

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