2 products were found matching "1414854-42-4"!

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Item number: Cay42234-10

A ROCK1 and ROCK2 inhibitor (Ki = 2 nM for both), selective for ROCK1 and ROCK2 over PKA, PKCtheta, MRCKalpha, and CaMKIV (Kis = 69, 9,332, 28, and 5,855 nM, respectively), decreases focal adhesion points on, and actin fiber length in, primary PTM cells at 1 µM, inhibits TGF-beta-induced increases in alpha-SMA...

Keywords:	AR-12286, N-(1,2-dihydro-1-oxo-6-isoquinolinyl)-a-(dimethylamino)-3-thiopheneacetamide
Application:	ROCK1 / ROCK2 inhibitor
CAS	1414854-42-4
MW:	327.4 D

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Verosudil

Item number: TGM-T60924-100mg

Description: Verosudil (AR-12286) is a highly potent Rho kinase (ROCK) inhibitor with a Ki of 2 nM and 2 nM against ROCK1 and ROCK2, respectively. AR-12286 mitigates steroid-induced intraocular pressure in mice by decreasing intraocular pressure through enhanced outflow of aqueous humor via the trabecular meshwork....

Keywords:	AR-12286
Application:	Antiglaucoma, Rho-associated kinase inhibitor
CAS	1414854-42-4
MW:	327.4 D

From 50.00€ *

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